"A genetic change that was identified in a triple-negative sample involved a fusion of two genes: MAGI3 and AKT3. The protein produced by this fusion gene is thought to contribute to cancer growth. When the researchers looked for this fusion gene in another set of tumor samples, they found it in 7% of triple-negative samples (5 out of 72).
Drugs that target this biological pathway are already being investigated for other purposes, and may eventually prove to be useful for triple-negative breast cancers that contain the fusion gene. If researchers are able to find a targeted drug that is effective against these cancers, it would be an important advance in the treatment of triple-negative breast cancer. Only a subset of triple-negative breast cancers contain the genetic change identified in this study, but ongoing research may identify additional targets."...
Susan G. Komen for the Cure | Potential New Target Identified in Triple-Negative Breast Cancer
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