Taking you through my Journey
to bring much awareness to
Breast Cancer
and that Early
Detection is key to survival.
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Saturday, March 23, 2013
1,6-Bisphosphate (FBP1), Key Enzyme Missing From Triple Negative Breast Cancer Cells
Dr. Peter Zhou
"Zhou's study, published in Cancer Cell, showed that the powerful transcription factor complex Snail-G9a-Dnmt1 is over-expressed in triple-negative breast cancer, inhibiting the enzyme 1,6-bisphosphate (FBP1). The loss of this enzyme shuts down the glucose anabolic pathway and promotes the glucose catabolic pathway, leading to a large amount of glucose entering the tumor cells and thus "feeding" the aggressive cancer. This metabolic switch empowers the triple-negative breast cancer cells to suck more glucose from the body, increasing macromolecule biosynthesis in tumor cells and maintaining ATP production despite a dearth of nutrients and an oxygen-free environment..."
