I promise

"I promise, Suzy... Even if it takes the rest of my life." - Nancy G. Brinker, Founder of Susan G. Komen for the Cure

What is Triple Negative Breast Cancer?


Just in recent years, Triple Negative Breast Cancer has sparked interest in the news where instead of calling the tumor as ER-negative, PR-negative, and HER2-negative; researchers began using the shorthand term, "Triple Negative," dubbed the "new type" type of cancer. Being Triple Negative, you don't have a targeted therapy and that your only treatment option is chemotherapy.

Triple Negative is seen in about 15% of all breast cancers. Triple Negative is a very aggressive cancer that tends to strike younger women, pre-menopause, especially among African-American women and women who have BRCA1 mutations. The tumor tends to be fast growing and is less likely to show up on an annual mammogram. TN is more likely to metastasis early on; has a high rate of recurrence in the first 2-3 years from diagnosis and has a poorer prognosis than other types of breast cancer due to lack of specific, targeted treatment for TNBC.

Sunday, June 23, 2019

YSC Conference Orlando 2018

Warm weather, palm trees,
and cool cars!

Celebrating 20 years of young survival coalition

YSC CEO, Jennifer Merschdorf

 #SquirrelPack4Life YSC reunion

Melissa and Dusty

Tammy, Melissa and Dusty

Until we see you again, Dusty

Tammie and TNBC sisters, Angie Martin, Melissa,
Alex and Jeanna

TNBC sisters Melissa and Karen Koon

Breast Cancer survivors
Tammie and Melissa

Breast Cancer can

#KissThis4MBC campaign

Kick Ass Survivor Melissa
advertising for Healing Heels

Kick Ass (in heels)

A Story Half Told
Remembering Jill Cohen


TNBC sisters Melissa, Jeanna, Sara and Lisa
advertising for Triple Negative Breast Cancer
Foundation and promoting

TNBC sisters with Roxanne on right

TNBC sisters Melissa and Laura D'Alessandro

TNBC sisters Melissa and Joanne Hayashi
"3 negative"

TNBC sisters Melissa and
Alison Mcquillan

TNBC sisters forever!
Angela Martin and Melissa

TNBC Sisters Angie, Melissa
and Laura

TNBC sisters Melissa and
Laura Shepard

Breast Cancer survivors
Melissa and Carol Capelan

Love this group of YSC survivor sisters!

Lookie here:
 HOPE in Triple Negative Breast Cancer

Immunomedics pipeline,
Hope in Triple Negative Breast Cancer

Preliminary data shows clinical benefit in patients
with mTNBC with Sacituzumab goviitecan
targeting Trop-2, an epithelial antigen expressed
on many solid tumors

ASCENT Phase 3 study recruiting
Metastatic TNBC patients

Metastatic Triple Negative Breast Cancer Background:
- 15% of all breast cancer cases
- Aggressive with poor prognosis
- Short response with rapid relapse, 
  visceral and brain mets are common
- Progression-free survival of 1.7 to 3.7 months
- Median overall survival of 10 to 13 months 

2017  Current studies of Standard of care
treatments for mTNBC:

- Carboplatin
- Docetaxel
- Cisplatin/carboplatin
- Ixabepilone
- Capecitabine
- Eribulin

Breast cancer sisters, Terlisa Sheppard 
and Melissa

I love the 90's theme
TNBC sisters Melissa and Jeanna Holler

Breast cancer sisters Melissa 
and Susan Portnoy

CEO of Young Survival Coalition,
Jennifer Merschdorf and Melissa

20 years of Young Survival Coalition!
Breast cancer sisters Melissa and Kelsey

In memory of YSC sisters
Lisa Barmettler and
Juls Raschal

Breast cancer sisters Jocelyn Banks
from the SCAR Project and
and Melissa

Breast cancer sisters Shay Sharpe, 
Melissa and Nikki Tripplett

TNBC sisters Melissa Richardson
and Melissa Paskvan

Breast cancer sisters Miri Mogilevsky
and Melissa

Speaker Julie Larson on what's NORMAL
in surviving breast cancer

Speaker Julie Larson on "And at the same time..."

Unconditionally love Life!

My forever #SquirrelPack4Life
Dusty, Melissa, Mary Peters, Jeanna, Angie Martin,
Alexandra , Sara, Lisa and Tammie

Thursday, June 20, 2019

Congrats Angelique on your Defense in TNBC Research

"Angelique, I am so impressed with your research in TNBC from your compound discovery to cause cancer cells to burst and flatten, reversing multi-drug resistance in metastatic TNBC when added to existing drugs, no significant changes in toxicity in mice models and reducing size and weight of the tumor.  This is huge for us survivors in the TNBC Community.  As a 10 year survivor of Triple Negative Breast Cancer, the fear of recurrence is real, all of us survivors fear it.  I have seen too many TNBC sisters pass after exhausting many clinical trials and a fierce battle.  
I am excited in the direction your research is going, this gives us much hope that this may be our targeted therapy.

Angelique has successfully defended her research defends in her doctoral thesis from Dr. Tiwari's lab on ‘Discovery of novel necroptosis inducers in triple negative breast cancer therapy’. Congrats Dr. Angelique on this incredible honor and receiving your PhD."    -Melissa

Angelique's Defense

Angelique and Melissa

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