I promise

"I promise, Suzy... Even if it takes the rest of my life." -Nancy G. Brinker, Founder of Susan G. Komen for the Cure

What is TNBC

WHAT IS TRIPLE NEGATIVE BREAST CANCER?

Just in recent years, Triple Negative Breast Cancer (TNBC) has sparked interest in the news where instead of calling the tumor as ER-negative, PR-negative, and HER2-negative; researchers began using the shorthand term, "Triple Negative," dubbed the "new type" of breast cancer. Being Triple Negative, you don't have a targeted therapy and your only treatment option is chemotherapy.

Triple Negative Breast Cancer is seen in about 15% of all breast cancers. TNBC is a very aggressive cancer that tends to strike younger women, pre-menopause, especially among African-American women and women who have BRCA1 mutations. The tumor tends to be fast growing and is less likely to show up on an annual mammogram. TNBC is more likely to metastasis early on; has a high rate of recurrence in the first 2-3 years from diagnosis and has a poorer prognosis than other types of breast cancer due to lack of specific, targeted treatment for TNBC.

Showing posts with label Triple Negative Breast Cancer research. Show all posts
Showing posts with label Triple Negative Breast Cancer research. Show all posts

Wednesday, May 5, 2021

Luncheon Celebration 2021

Finally got together on March 30, 2021 with these amazing cancer researchers of The University of Toledo, celebrating Dr. Amit Tiwari's $1.4 million DOD grant fund awarded to continue their preclinical study to have a better understanding of how the chemical structure of his promising drug discovery targets a certain protein to induce cancer cell death in Triple Negative Breast Cancer (TNBC) cells.

As a patient advocate, I am excited to share with our TNBC Community, Dr. Tiwari has discovered a compound that causes a unique cancer cell death where the cells swell and burst. With this approach, markers are released that signals the body's immune system to target and destroy even the most resistant Triple Negative Breast Cancer cells.  Thus far, this has been proven effective in mice models and human cancer cells in the lab.

Dr. Tiwari's compound discovery of overcoming multi-drug resistance that has often been seen in Triple Negative Breast Cancer, brings much hope to us TNBC survivors.  We need to continue to support Dr. Tiwari and his team to advance their research to human clinical trials.  We so need better treatment options when current chemotherapy treatments stops working. 

Dr. Raman, Dr. Tang, Melissa and Dr. Tiwari

"Thank you Melissa for sharing our wonderful meeting with you, Drs. Raman and Tang. They were equally delighted to meet you.  Thank you for community outreach and being an integral part of our team.  We are blessed to have you."         
- Dr. Amit K. Tiwari

Tuesday, March 23, 2021

UT College of Pharmacy and Pharmaceutical Sciences Faculty Spotlight

 Shout out to Dr. Amit K. Tiwari for his continued promising research against Triple Negative Breast Cancer!



"Thank you Melissa.  Breast Cancer Research advocate like you keep me and my team moving.  You are such a blessing to have.  Thank you!"
- Dr. Amit K. Tiwari

Tuesday, January 26, 2021

The University of Toledo's Researcher, Dr. Amit Tiwari Awarded $1.4 Million to Advance Research in Promising New Chemotherapy for Triple Negative Breast Cancer

 

Melissa Paskvan 
and Dr. Tiwari
My TNBC researcher here in Toledo was just awarded another grant, this time from U.S. Department of Defense for $1.4 million to further his research in overcoming drug resistance in treatment therapy in Triple Negative Breast Cancer.  I am so proud to be a part of University of Toledo's Dr. Amit Tiwari's research team as their Patient Advocate Mentor for continued research on Triple Negative Breast Cancer.  Congratulations to D. Tiwari and his amazing team! I am glad that we found each other as partners in this fight against TNBC!

(Click link to story) 

UToledo Awarded $1.4 Million to Advance New Chemotherapy for Difficult-to-Treat Breast Cancer


"We are glad that you are part of our team.  Thank you for your wonderful spirit and passion to keep us moving forward." - Dr. Amit K. Tiwari


Friday, March 6, 2020

University of Toledo Research Lab Visit February 20, 2020


Dr. Tiwari's Lab

Triple Negative Breast Cancer Research
at Dr. Amit Tiwari's lab

Storing Triple Negative Breast
Cancer cells for future studies

TNBC Researcher, Saloni marking
vials of Triple Negative Breast
Cancer cells

Counting Triple Negative Breast
Cancer cells under the microscope

Triple Negative Breast Cancer cells
on the rocking Shaker

Saloni removes Triple Negative 
Breast Cancer cells from 
the rocking shaker

Wednesday, February 5, 2020

Triple Negative Breast Cancer Research at The University of Toledo 2019

Triple Negative Breast Cancer Research taking
place here at the University of Toledo's
Wolfe Center

U of Toledo's Wolfe Center
College of Pharmacy and
Pharmaceutical Sciences

"DNA Molecule"

Saloni testing TNBC cells in
a sterile setting

Saloni performing an experiment on
triple negative breast cancer cells

Saloni looking at TNBC cells
under the microscope
in Dr. Tiwari's lab

Thursday, August 1, 2019

Young Researchers in Triple Negative Breast Cancer 2019

It's always an honor to go to University of Toledo's Pharmaceutical Science research lab and see first hand what they are working on and the progression of their studies. On July 3, 2019, Dr. Angelique treated me lunch on campus the day before she was about to leave UT for Boston where she will continue her career in pharmaceutical research and wishes to continue her research in Triple Negative Breast Cancer.  Saloni of UT will continue researching drug resistance in Triple Negative Breast Cancer in Dr. Amit Tiwari's lab.

Melissa and Dr. Angelique 
in her research office

Triple Negative Breast Cancer cells
under the microscope

Saloni viewing results of her study on
Triple Negative Breast Cancer cells

Untreated Triple Negative Breast Cancer Cells

Triple Negative Breast Cancer cells
after being treated with an experimental drug,

destroying the cancer cells.  

Sunday, June 23, 2019

YSC Conference Orlando 2018




Warm weather, palm trees,
and cool cars!

Celebrating 20 years of young survival coalition

YSC CEO, Jennifer Merschdorf

 #SquirrelPack4Life YSC reunion

Melissa and Dusty

Tammy, Melissa and Dusty

Until we see you again, Dusty

Tammie and TNBC sisters, Angie Martin, Melissa,
Alex and Jeanna

TNBC sisters Melissa and Karen Koon

Breast Cancer survivors
Tammie and Melissa
#KissThis4MBC

Breast Cancer can
#KissThis4MBC!

#KissThis4MBC campaign

Kick Ass Survivor Melissa
advertising for Healing Heels
https://www.healing-heels.com

Kick Ass (in heels)

A Story Half Told
Remembering Jill Cohen

https://www.storyhalftold.com/meet-jill-cohen

TNBC sisters Melissa, Jeanna, Sara and Lisa
advertising for Triple Negative Breast Cancer
Foundation and promoting
#TNBCDay
https://www.tnbcfoundation.org

TNBC sisters with Roxanne on right

TNBC sisters Melissa and Laura D'Alessandro

TNBC sisters Melissa and Joanne Hayashi
"3 negative"

TNBC sisters Melissa and
Alison Mcquillan

TNBC sisters forever!
Angela Martin and Melissa

TNBC Sisters Angie, Melissa
and Laura

TNBC sisters Melissa and
Laura Shepard

Breast Cancer survivors
Melissa and Carol Capelan

Love this group of YSC survivor sisters!

Lookie here:
 HOPE in Triple Negative Breast Cancer

Immunomedics pipeline,
Hope in Triple Negative Breast Cancer

Preliminary data shows clinical benefit in patients
with mTNBC with Sacituzumab goviitecan
targeting Trop-2, an epithelial antigen expressed
on many solid tumors

ASCENT Phase 3 study recruiting
Metastatic TNBC patients
http://tnbctrial.com

Metastatic Triple Negative Breast Cancer Background:
- 15% of all breast cancer cases
- Aggressive with poor prognosis
- Short response with rapid relapse, 
  visceral and brain mets are common
- Progression-free survival of 1.7 to 3.7 months
- Median overall survival of 10 to 13 months 

2017  Current studies of Standard of care
treatments for mTNBC:

- Carboplatin
- Docetaxel
- Cisplatin/carboplatin
- Ixabepilone
- Capecitabine
- Eribulin

Breast cancer sisters, Terlisa Sheppard 
and Melissa

I love the 90's theme
TNBC sisters Melissa and Jeanna Holler

Breast cancer sisters Melissa 
and Susan Portnoy

CEO of Young Survival Coalition,
Jennifer Merschdorf and Melissa

20 years of Young Survival Coalition!
Breast cancer sisters Melissa and Kelsey

In memory of YSC sisters
Lisa Barmettler and
Juls Raschal

Breast cancer sisters Jocelyn Banks
from the SCAR Project and
http://www.mommyhasbreastcancer.org
and Melissa

Breast cancer sisters Shay Sharpe, 
Melissa and Nikki Tripplett

TNBC sisters Melissa Richardson
and Melissa Paskvan

Breast cancer sisters Miri Mogilevsky
and Melissa

Speaker Julie Larson on what's NORMAL
in surviving breast cancer

Speaker Julie Larson on "And at the same time..."

Unconditionally love Life!

My forever #SquirrelPack4Life
Dusty, Melissa, Mary Peters, Jeanna, Angie Martin,
Alexandra , Sara, Lisa and Tammie

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