What is Triple Negative Breast Cancer?

Denise Wolf Honored at Tri-Valley Socks "Bras for the Cause" 2013

2013 Tri-Valley Socks "Bras for the Cause" honoree is one of my Triple Negative Sisters, Denise Wolf. Denise own battle with TNBC inspired her to switch her career and become a Breast Cancer Researcher herself.  It is Denise's desire to help along with her UCSF team of doctors to develop customized chemo treatments tailored to an individual patient in hope of improving their odds of survival of aggressive breast cancers. Denise is a huge asset to our online support group, always offering support and addressing our concerns on with her insights on Triple Negative Breast Cancer... Denise is so deserving of being named Honoree of her local breast cancer fund raising event. Thank you Denise for being our voice in our fight against TNBC. Please read Denise's inspiring story in full by clicking on it's link below.

Denise Wolf

"...Offering valuable moral support throughout the cancer care chain is another task she has taken to heart as an unofficial online adviser to women’s support groups, including Triple Negative Breast Cancer Foundation (TNBCF) and the Facebook community “Triple Negative Sisters.” She finds it very rewarding to be able to answer questions and provide the hands on support that only a cancer survivor can offer. “Our oncologists and surgeons are advisors, yes, but we and our network of family and friends become the real caregivers. You owe it to yourself to be informed.”




 http://www.independentnews.com/community/article_d63c41fa-b355-11e2-a3b1-001a4bcf887a.html (Click link to full story)

Denise Wolf profiled as Honoree for "Bras for a Cause"
http://www.trivalleysocks.org/WalkDedication_2013.html 
 (Click link to story)

Making Strides Against Breast Cancer Northwest Ohio 2013

Making Strides Against Breast Cancer of Northwest Ohio raised $77,252.76 at their 7th annual event on May 11, 2013.

"Yes, I am!" - Melissa Paskvan

"Because I love you all!"

Melissa and high school friend,
 Rhonda

Triple Negative Breast Cancer
sister, Genny and Melissa

Inflammatory Breast Cancer survivor friend,
Kathleen Walsh was honoree for  2013 Making
Strides Against Breast Cancer

Melissa Paskvan
"Look at those cool socks!"

TRIPLE NEGATIVE BREAST CANCER 05/06 by Stupid Cancer Show | Blog Talk Radio

TRIPLE NEGATIVE BREAST CANCER 05/06 by Stupid Cancer Show | Blog Talk Radio My TNBC sister, Rachel Pappas in the the spot light.


 

Listen to internet radio with Stupid Cancer Show on BlogTalkRadio


Join us as we open the floodgates to expose Triple Negative Breast Cancer, a misunderstood variant of the disease that affects up to 25,000 women each year. We will be joined by Hayley Dinerman (Executive Director), Malaak Compton-Rock (Board Member) and Dr. Lisa Newman (Scientific Advisory Board) from the Triple Negative Breast Cancer Foundation. TNBC young adult survivor Rachel Pappas in the spotlight.

Janelle Wade's Fight with Triple Negative Breast Cancer

One of my Triple Negative Breast Cancer sister hopes her story of TNBC helps raise awareness. 

8 News NOW

"...Wade says she stays positive with the help of her family and friends, many who took part in the Susan G. Komen Race for the Cure last year. Now she hopes her story will also help raise awareness. She encourages others to be aware of their bodies and to see a doctor if something doesn't feel right..."

http://www.8newsnow.com/story/22111243/woman-fights  
(Click link to story)

Tamoxifen's Role in Triple-Negative Breast Cancer

Published on May 1, 2013

Mark Noble, Ph.D., professor of Biomedical Genetics at the University of Rochester Medical Center, discusses the potential of tamoxifen in fighting triple-negative breast cancer (also known as basal-like breast cancer). 

http://www.urmc.rochester.edu/news/story/index.cfm?id=3802
(Click link to story)

Bio-Path's Plan to Develop Liposomal Grb-2 as a Targeted Therapy Against Inflammatory Breast Cancer and Triple Negative Breast Cancer

"...Focusing on its longer-term pipeline, the Company announced it is initiating development of its lead cancer drug BP-100-1.01 (Liposomal Grb-2) to treat triple negative breast cancer (TNBC) and inflammatory breast cancer (IBC), two cancers characterized by formation of aggressive tumors and relatively high mortality rates. Bio-Path’s plan is to develop Liposomal Grb-2 as a targeted therapy against TNBC and IBC. Treatment goals are two-pronged: the first being to develop Liposomal Grb-2 as a tumor reduction agent in combination with other approved drugs in pre-operative settings, and the second is to develop Liposomal Grb-2 as a drug to treat and control or eliminate cancer metastasis in TNBC and IBC patients. Both of these treatment goals address high need situations for patients..."



http://www.rxir.com/SSI/ClientPR/201324102455.shtml (Link to story)

http://bionews-tx.com/news/2013/04/04/bio-path-holdings-expands-reach-of-non-toxic-md-anderson-tested-cancer-treatment/ (Link to story)

http://finance.yahoo.com/news/bio-path-shares-attractive-now-153340813.html (Link to story)

http://seekingalpha.com/instablog/685353-grant-zeng/1572271-bio-path-shares-are-attractive-now (Link to story)

Komen's Research Fast Facts: Triple Negative Breast Cancer

Thank you Komen...

Susan G. Komen® | Prognosis of Triple-Negative Breast Cancer Varies By Age

Komen News press release:

Prognosis of Triple-Negative Breast Cancer Varies By Age

The prognosis of triple-negative breast cancer (TNBC) tends to be better among older women than among younger women, even though older women are less likely to receive aggressive treatment. These results were published in Breast Cancer Research and Treatment. 

Previous studies have reported that the prognosis of breast cancer tends to be better for women who are diagnosed at older ages, but few of these studies have focused specifically on triple-negative breast cancers (breast cancers that are estrogen receptor-negative, progesterone receptor-negative, and HER2-negative).  

The explore the relationship between age and prognosis, researchers conducted a study among 1,732 women with TNBC. Roughly 21% of the women were age 40 or younger at the time of diagnosis. 

Factors that were more common among younger women included non-white race, high-grade tumors, and treatment with chemotherapy.  

In spite of receiving more aggressive treatment, younger women tended to have worse disease-free and overall survival than older women. Median disease-free survival (survival without a recurrence or a new cancer) was 4 years among women who were diagnosed between ages 31 and 40, compared with 8 years among women diagnosed at age 60 or older. 

The relationship between age and prognosis persisted even after accounting for factors such as family history of breast cancer, tumor grade and size, and lymph node involvement.  

As has been reported for other types of breast cancer, older age tends to be linked with better outcomes among women with TNBC. Research into how the biology of TNBC varies by age may point the way toward new and more effective treatments for this condition. 

Reference: Liedtke C, Hess KR, Karn T et al. The prognostic impact of age in patients with triple-negative breast cancer. Breast Cancer Research and Treatment. Early online publication March 5, 2013. 

Posted March 19, 2013

Susan G. Komen® | Prognosis of Triple-Negative Breast Cancer Varies By Age

Stronger...

Melissa Paskvan is Going to Bat Against Breast Cancer 2013...

It's that time again... I'm going to bat against breast cancer until all of my sisters are safe. I'm going for honorary bat girl for the Detroit Tigers and I would appreciate your vote please. Thank you ♥
http://mlb.mlb.com/honorarybatgirl/2013/gallery.jsp 
(Click link to vote)

I Want Your VOTES!

In 2009, I found my lump by chance when I felt something along my bra band line under my breast. My heart just sunk, and I was in disbelief that my worst fear was now happening to me. I reacted fast and got in for a mammogram and an ultrasound 2 days later.  My 2cm. lump did not show up on the mammogram images, and it was thought to be just a cyst, but I insisted on a needle biopsy right then and there. I received that call from my doctor, I'm 41 and I have breast cancer... I was numb.  I was told that I have a rare and aggressive form of cancer ,Triple Negative Breast Cancer (TNBC), that tends to strike younger women. I opted for a lumpectomy, followed by chemotherapy, 33 radiation treatments and a clinical trial.  I am so passionate about putting Triple Negative Breast Cancer Awareness in the forefront  that I go to bat  for all of my sisters that are still battling. I have participated in many events including Komen for the Cure, Making Strides Against Breast Cancer, Relay for Life and most recently, Triple Negative Breast Cancer Inaugural Awareness Day where I raised $605 for the TNBC Foundation. I have created a blog documenting my journey to help others to have hope, give them strength to fight and to provide resources to get them the information they need to to know more about this TNBC subtype.  I'm going to bat until all of my sisters are safe... Breast self-exams saves lives! Now, let's play ball!

"As More Women Are Beating Breast Cancer, Survival Rates Among Triple Negative Breast Cancer Patients Have Not Improved For Many Women

"Only 10 to 20 percent of breast cancers are triple negative, but black women are twice as likely as white women to develop it. And women under 40 are twice as likely to get this type sub-type..."



http://wtvr.com/2013/04/06/buddy-check-6-breast-cancer-survival-rates-not-improving-for-some/ (Click link to story)

Do you Know Your Risk for Breast and Ovarian Cancer?

Assess Your Risk

This interactive tool was created to take you on a journey and help you better understand some of the common factors that can influence your personal cancer risk. By combining your family's health history and accounting for lifestyle factors, you will not only learn more about your risk, but also what actions you can take starting today to be brighter with your breast and ovarian health.

Disclaimer: This tool is available for educational purposes only and should not be interpreted as medical advice. Be sure to partner with your medical provider to develop the best personal care strategy for you.

http://www.brightpink.org/knowledge-is-power/assess-your-risk/ 
(Click link to quiz)

Dr Lisa Newman research on Triple Negative Breast Cancer in African-American Women and women of Ghana, Africa

Stroll for Strides Against Breast Cancer 2013

"Hello, welcome to Chico's. My name is Melissa and I
am a 3½ yr. Triple Negative Breast Cancer Survivor!"

I participated in Stroll for Strides as a breast cancer survivor store greeter at Chico's of Levis Commons, Perrysburg as part of their scavenger hunt event for prizes and store discounts. An evening of good company and yummy appetizers with my survivor friends from The Victory Center. 

Melissa and Making Strides Honoree, Kathleen Walsh.
Kathleen is an Inflammatory Breast Cancer Survivor
whom I've met in our support group at The Victory Center.

My Story and my message to you...