What is Triple Negative Breast Cancer?
WHAT IS TRIPLE NEGATIVE BREAST CANCER?
Just in recent years, Triple Negative Breast Cancer has sparked interest in the news where instead of calling the tumor as ER-negative, PR-negative, and HER2-negative; researchers began using the shorthand term, "Triple Negative," dubbed the "new type" type of cancer. Being Triple Negative, you don't have a targeted therapy and that your only treatment option is chemotherapy.Triple Negative is seen in about 15% of all breast cancers. Triple Negative is a very aggressive cancer that tends to strike younger women, pre-menopause, especially among African-American women and women who have BRCA1 mutations. The tumor tends to be fast growing and is less likely to show up on an annual mammogram. TN is more likely to metastasis early on; has a high rate of recurrence in the first 2-3 years from diagnosis and has a poorer prognosis than other types of breast cancer due to lack of specific, targeted treatment for TNBC.
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Friday, January 16, 2015
Tuesday, January 13, 2015
Wellcome Trust Sanger Institute, UK
"The team looked at breast cancers from almost 3000 patients. Their search had a particular focus: they examined changes to genes that affect the behaviour of stem cells and developing tissues, because other work they have done suggests that such genes, when mutated, can often drive cancer development. Among these was BCL11A.
"Our understanding of genes that drive stem cell development led us to search for consequences when these genes go wrong," says Dr Pentao Liu, senior author on the study, from the Wellcome Trust Sanger Institute. "BCL11A activity stood out because it is so active in triple-negative cancers.
"It had all the hallmarks of a novel breast cancer gene."Higher activity of the BCL11A gene was found in approximately eight out of ten patients with basal-like breast cancer and was associated with a more advanced grade of tumour. In cases where additional copies of the BCL11A gene were created in the cancer, the prospects for survival of the patient were diminished..."
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My Favorite Breast Cancer Sites
- Triple Negative Breast Cancer Foundation
- Young Survival Coalition
- Living Beyond Breast Cancer
- Susan G. Komen for the Cure
- 1 Up on Cancer
- Triple Step Toward The Cure
- American Cancer Society Making Strides Against Breast Cancer
- The Victory Center
- Renee's Survivor Shop
- Relay for Life
- The SCAR Project
- CURE makes cancer understandable
- BREASTCANCER.ORG Discussions Boards
- Jennifer Griffin's Blog
- Positives about Negative
- National Breast Cancer Foundation
- Breast Cancer
- Breast Cancer Fund
- The Breast Cancer Site
- Food for Breast Cancer
- Breast Cancer Awareness Body Painting Project
- Ford Warriors in Pink
- Feel Your Boobies