I promise

"I promise, Suzy... Even if it takes the rest of my life." -Nancy G. Brinker, Founder of Susan G. Komen for the Cure

What is TNBC

WHAT IS TRIPLE NEGATIVE BREAST CANCER?

Just in recent years, Triple Negative Breast Cancer (TNBC) has sparked interest in the news where instead of calling the tumor as ER-negative, PR-negative, and HER2-negative; researchers began using the shorthand term, "Triple Negative," dubbed the "new type" of breast cancer. Being Triple Negative, you don't have a targeted therapy and your only treatment option is chemotherapy.

Triple Negative Breast Cancer is seen in about 15% of all breast cancers. TNBC is a very aggressive cancer that tends to strike younger women, pre-menopause, especially among African-American women and women who have BRCA1 mutations. The tumor tends to be fast growing and is less likely to show up on an annual mammogram. TNBC is more likely to metastasis early on; has a high rate of recurrence in the first 2-3 years from diagnosis and has a poorer prognosis than other types of breast cancer due to lack of specific, targeted treatment for TNBC.

Thursday, April 25, 2019

American Association for Cancer Research Atlanta Annual Meeting 2019


My first American Association for Cancer Research (AACR) Annual Meeting 2019 experience...  A Global Alliance Partnership

Welcome to Atlanta!

Triple Negative Breast Cancer sisters,
Melissa and Natalia Munoz

I learned so many little things but are huge to me as I continue to get a better understanding of cancer research and my role as a patient advocate mentor by attending AACR Annual Meeting 2019 in Atlanta, GA.  I thank University of Toledo's Dr. Amit Tiwari and his two researchers, Noor and Mariah for their enlightenment and guidance to the world of science collaboration. This exposure to AACR and continued engagement in cancer research community reaffirms my belief that knowledge is power and I'm excited to be a part of Dr. Tawari's team!

Researchers of today and tomorrow's medicine

Dr. Tiwari's research team and collaborators 

I learned that this was not only a conference on cancer research, but a convention bringing researchers, scientists and medical doctors from all over the world to one place to collaborate innovative therapies, share their research investigations, findings and ideas to accelerate the common goal by all, to find better treatments and ultimately a cure for all cancers. I firmly believe that these researchers are really working hard in trying new methods of combining molecules with existing chemotherapies and repurposing an existing drug treated for another medical illness and using it for cancer treatment research at lower dosage levels.

Welcome to George World Congress Center!




I was truly amazed and a little overwhelmed by the magnitude of this annual convention and the size of the convention center, Georgia World Congress Center.  I learned from an attendee that by Saturday morning that there was 22,000 people were registered for the conference and people were still registering. A few days later, I learned from a colleague that there was actually approximately over 42,000 people registered for this 6 day event.
The convention center itself was over 3 buildings long with multiple floor levels with several escalators that were always full of guests getting to a session from building A of the center to the opposite end, building C a couple of floors below to attend the poster sessions and exhibits hall. Just to give you and idea in how large this place was, For the 4 days of my attendance I felt like I was walking the Atlanta Airport back and forth all day long.

Noor, Melissa and Mariah

Melissa attending ACCR Meeting

This is only about a 3rd of the people that were
in attendance at the Opening Plenary

AACR Opening Plenary -  3% of patients participate in clinical trials!

Advocacy panel

So true!

I attended a session on patient advocacy...

- Why do we advocate? For more federal funding for cancer research.  "We cannot afford to not advocate."
- Advocacy is way of communication of results, research findings.
- Patient survivor advocacy gives a face to the issue. Share your story and make it personal.  Tell why the issue is important to you you and the impact of that research being done.
- Jargon is not important
- The impact of work is more important than the minor experimental details.

- Be educated and continue relationships with law offices and legislators.  Who are we meeting with and what issues are important to legislators... Take home message. "Urge their support for robust, sustained, and predictable funding increases for the NIH."
- We advocate for a community, represent a community (breast cancer)
- Telling your personal story opens the dialogue and captures their attention on the issue... Broaden it out, your story is just 1 example.
- Shared stories highlight - "how advances in scientific knowledge translate into patient survival."
- Advocate on social media and share our efforts tag leaders and thank them on Twitter.
- Advocates are doing posters at AACR.

Survivor and Scientists > Advocacy Partnership
Scientists communicating their sciences to the lay public
- Terminology - use smaller words
- Translating the science language
- Advocate to bridge the gap between the discoveries made in the lab and the person hearing about them
- Advocacy to include communication, prevention and early detection
* Cancer is not one disease
- Survivors are powerful to disseminate information to the community

Higher incidence rate of Triple Negative Breast
cancer in Black women

All women should be evaluated for breast
cancer no later than age 30

I attended a session of Postpartum Breast Cancer - Update on young women breast cancer
- Pregnancy is a risk for breast cancer in young women
* Ibuprofen to prevent postpartum breast cancer?
- Higher incidence of TNBC in young women
- TNBC is a component of poor prognosis... but, is not the driving factor for poor prognosis.

Breast cancer in black women 
- Higher mortality even with early stage of diagnosis.
- Higher incidence of TNBC 

* 2018 Recommendations by the American College of Radiology
"All women, especially black women and those of Ashkenazi Jewish descent, should be evaluated for breast cancer risk no later than age 30,  so that those at higher risk can be identified and can benefit from supplemental screening."


Dr. Hope Rugo,a well-known
TNBC Expert

Wearing yellow is nationally known TNBC expert,
Dr. Olufonmilayo Olopade, MD

Triple Negative Breast Cancer sister, Denise Wolf
speaking at AACR Meeting

Denise Wolf presenting I-Spy2 trials in
Triple Negative Breast Cancer

I-SPY 2 trials among recent TNBC trials
showing increased efficacy

Platinum-based therapy and Immunotherapy
graduated in Triple Negative Breast Cancer
51% estimated pCR in Veliparp/Carboplatin in TN
60% estimated pCR in Pembrolizumab in TN

Biomarkers determines drug therapy in
Triple Negative Breast Cancer

Triple Negative Breast Cancer sister's
Melissa and Denise Wolf

I was excited to read in the sessions book that a few well-know TNBC experts were speaking at AACR and I just had to attend and see what they were presenting.  Dr. Hope Rugo, Dr. Olufunmilayo Olopade and Denise Wolf who is a personal friend of mine who spoke on I-SPY 2 trials in TNBC.  I also, spotted another well-know TNBC expert, Dr. Joyce O'Shaughnessy  walking into Denise's session.

Researchers presenting their work at their
poster sessions

Virgie Townsend presenting her poster of her
becoming an advocate for cancer research 

Before the conference, I didn't know what the "posters" and sessions was all about until I saw from a window above of all the posters posted on board displays, row after row after row.  Of course, I had to go see see what that was all about as I went down stairs to get a close-up look of these posters.  These Posters were actual presentation studies of the researchers work explaining their cancer research and their findings of the drug treatments performed in the lab.  I've noticed on some of the poster boards that there was a statement, "Do not post on Social Media" attached to their poster to protect their research work from being reproduced by another.
My research colleague, Noor presented her poster at a session outlining her studies and walked me through her poster findings of her research and explained everything to me for my understanding. 
I did see a Poster by Texas A&M University Health Science Center on a phase 2 clinical trial in TNBC patients, investigating dose-limiting toxicities and efficacy of their drug combination chemo-refractory. 
I stopped and spoke to a breast cancer advocate and a breast cancer survivor volunteer telling about how they became involved in advocacy and volunteering for well know breast cancer organizations.

Posters and Exhibits hall

From Our Bench to Your Bench ®

ThermoFisher

Immuno-Oncology research

Genetech on cancer immunotherapy

Atezolizumab, an Anti-PDL1 cancer
immunotherapy trials for TNBC

MD Anderson Cancer Center

I was really blown away by the exhibit hall with all of the elaborate and spectacular exhibits, I often compared it to how spectacular it is to the Detroit Auto Shows I've attended in the past.  Walking around and visiting some of these exhibits of the latest cancer clinical studies that are available to the latest technology of the latest medical products that are available and demonstrating their usage. Immunotherapy and cancer imaging was huge at the exhibits presentation.  Seemed like everyone was on board with Immunotherapy with the latest treatment research in treating cancer.  

Genentech exhibit displayed a wall size poster stating that they were now enrolling patients with Triple Negative Breast cancer for Atezolizumab, an Anti-PDL1 cancer immunotherapy trials.
1. as a First-Line therapy in metastatic TNBC
2. as Adjuvant/Neoadjuvant therapy in Early TNBC

Working together for better treatments
and a cure for all cancers

Thank you Atlanta for hosting AACR
Meeting 2019 and thank you Komen for
continued support and funding for
breast cancer research


Saturday, April 20, 2019

Komen's Power of the Promise 2019

On April 11, 2019, I attended Komen's Power of the Promise benefit, and was honored to be a guest of Dr. Amit Tiwari at his table of University of Toledo's Triple Negative Breast Cancer researchers. 
Dr. Amit Tiwari and his research team were recognized for their Komen funded research on overcoming drug resistance in Triple Negative Breast Cancer.  The support of each table of attendees stood up arounds us, clapping their hands got me a little teary-eyed... brought me much hope that is so needed in our breast cancer community. 
.
Dr. Tiwari's breast cancer research team:
Angelique, Saloni and Melissa

Dr. Tiwari being recognized for his research on
Triple Negative Breast Cancer

Susan G. Komen National Scholar,
 Dr. Wayne Doran shares his story of being
a 10-year male breast cancer survivor

Elliot, ArtBeat Live!

Toledo's Skyline auctioned for $2000 benefiting
Komen Northwest Ohio

Amy and Gretchen of Komen 
Northwest Ohio

Komen Northwest Ohio Board President,
 Amy Thorpe Wiley and Melissa

Melissa and Mary Westphal, Executive 
President of Komen Northwest Ohio

Melissa and Gretchen Awad of Komen
Northwest Ohio

Desmond of Komen Northwest Ohio
and Dr. Tiwari

Melissa and Chrys Peterson

Researchers and friends of Dr. Tiwari's team

Dr. Tiwari's researchers and TNBC survivors

Power of the Promise... Destroying Triple Negative Breast Cancer Cells

Some really great research on drug resistance in Triple Negative Breast Cancer by Dr. Amit Tiwari and his research team happening at The University of Toledo!


Click to Link: http://utnews.utoledo.edu/index.php/09_26_2018/breakthrough-research-at-ut-shows-promise-in-treating-drug-resistant-form-of-deadly-breast-cancer

Monday, March 25, 2019

Drug Resistance in Metastatic Triple Negative Breast Cancer Research 2019

In August of 2017, Mary Westphal, Executive Director of Komen of Northwest Ohio connected me with Dr. Amit Tiwari, Assistant Professor of University of Toledo Department of Pharmacology and Experimental Therapeutics.  Dr. Tiwari contacted me in regards to a research project that he has been researching for a few years on Drug Resistance in Metastatic Triple Negative Breast Cancer.  I immediately was eager to learn more on his research since this was the type of breast cancer I was diagnosed with in 2009.  I agreed to meet up with Dr. Tiwari and his assistant researcher, Angelique for lunch where he presented to me his research, overcoming drug resistance in Triple Negative Breast Cancer cells in a culture dish setting.  
Dr. Tiwari was ready to continue his research, moving on to testing in mice models and ultimately to human clinical trials but needed additional financial support and was in the process of applying for a Komen national grant that would further his research.   A part of the stipulation of the Komen grant was that his research would have to have a Patient Advocate Mentor on his team and asked me if I was interested in taking on this role, as I have been very active in the Triple Negative Breast Cancer community.  Without hesitation I asked,  "where do I sign?"  I was so honored to be asked to be a part of his research team and immediately started working on my bio-sketch of my involvement in breast cancer events,  awareness, conferences, volunteering, fundraising and public speaking over the years since my diagnosis in 2009.  In September 2017, Dr. Tiwari submitted his grant application along with his 120+ pages of his research proposal that included my bio-sketch for review to Komen National Headquarters and then we wait for the response...  

In the meantime, Dr. Tiwari and I have met several times discussing his research, my role as his Patient Advocate Mentor and introduced to me members of his research team at The University of Toledo Department of Pharmacology and Experimental Therapeutics and gave me a tour of his research lab.  Also, I had the opportunity to view live Triple Negative Breast Cancer cells under the microscope that appeared to be forming clusters.  

Almost a year later in September 2018, Dr. Tiwari notified me that he was awarded nearly $450,00.00 to continue his research on Drug Resistance in Metastatic Triple Negative Breast Cancer... and had recently discovered a molecule that reverses the drug resistance and making it more responsive to treatment.  I am just ecstatic that there is a potential cure for Triple Negative Breast Cancer and that this research is happening in my own back yard so to speak!  I have been longing for TNBC research in Toledo ever since I was diagnosed and no effective targeted therapy has been yet to be discovered.  I want to commit myself to this project and be involved in as much as possible to expand my understanding of how this research progresses and continue to learn as much as I can to better assist Dr. Tiwari, his team and our local breast cancer community.

Recently, I have attended a lab meeting learning about the different experiments that they are studying.  Also, I sat in and observe an experiment on bone marrow cells performed by Dr. Diwakar Tukaramrao.  My observation of the experiment was very interesting in seeing  firsthand how testings are prepared and the amount of preparation is done before the actual testing is performed.  I learned about how cells must be kept at 37℃ in freezers, refrigerators, incubators and be kept on ice when transporting.  I learned that some cells are light sensitive and are stored in amber colored glass bottles, and the lights in the testing sterile area needs to be turned off during testing exposure.  Also, I assisted in the lab with preparation by putting testing tubes in its multiple storage racks that were needed by another researcher, Mohammed.

I have always said my fight is not over until all my TNBC sisters are safe.
Stay tuned to my blog with updates of progress and my participation in this TNBC study. Truly, Melissa

Melissa looking at live Triple Negative Breast 
Cancer cells under the microscope

Melissa looking at colon cancer 
cells in the research lab

Melissa and Dr. Amit Tiwari


Assisting Kyle with keeping
research cells on ice to reduce
apoptosis 


Live cells handled from 
37℃ freezer to ice


Observing a research experiment
with Dr. Diwari Tukaramrao
and Kyle

Angelique presenting her studies on
Triple Negative Breast Cancer cells


Friday, March 22, 2019

Panel Discussion on Medical Updates on Breast Cancer Treatments 2018

On October 25, 2018, I attended a program at University of Toledo Dana Cancer Center on Individualized Breast Cancer Treatments with their professors and medical team.
A lot of advancement in breast-conserving surgeries that are currently being used in treatments. Also, the genetics of a cancer tumor is furthering research advancement in individualized drug therapies.  Below are  few screen shots of power points that were being discussed.

Pros and con of radiation therapy...

The way we treated breast cancer in 1882 to
the advancements and discoveries over
the years

The genetic make-up of a breast cancer tumor
is changing the way of research to
discover targeted therapies

Triple Negative Breast Cancer research
in trials for:BRCA positive, PIK3CA mutations
and Immunotherapy

30% of patients with early stage breast cancer
will experience a recurrence within
5 years of diagnosis, but...

Living Beyond Beast Cancer Conference Philadelphia 2018

On September 28, 2018, I attended the Living Beyond Breast Cancer Conference that was co-hosted by The Triple Negative Breast Cancer Foundation in Philadelphia. A lot of  promising research is still ongoing for Triple Negative Breast Cancer... PARP Inhibitors was FDA approved in October 2018 for BRCA positive metastatic TNBC.  Immunotherapy and Antibody-drug conjugates is also emerging in TNBC clinical trials with favorable results in complete response in metastatic Triple Negative Breast Cancer. 


My beautiful hotel room view of
Philadelphia skyline

No One Fights Alone!
TNBC sisters Sara K. and Melissa

Hayley Dinerman, Co-founder and President of
Triple Negative Breast Cancer Foundation
https://tnbcfoundation.org

Diagnosed with Triple Negative Breast Cancer
before the age of 60?

Promising Immunotherapy research
for TNBC still in clinical trials

The safety of Pembrolizumab Monotherapy
has demonstrated as being  favorable as
a first-line therapy with PD-L1 positive
Metastatic Triple Negative Breast Cancer.

Breast Cancer Oncologist, Reshma L. Mahtani
Identifying the different subtypes
of Triple Negative Breast Cancer

PARP Inhibitors as an emerging target for
Metastatic TNBC patients that are also
BRCA positive of the gene mutation

Most breast cancer in African women are
triple negative

Who's at higher risk of Triple Negative
Breast Cancer?

Brain metastases is much higher in advanced
Triple Negative Breast Cancer than
other breast cancer subtypes

Me and the ladies of the TNBC Foundation
Allison Axenrod,  Amy Mustica, Melissa Paskvan,
Arlene Brothers and Hayley Dinerman

Fighting for a TNBC
targeted therapy breakthrough!

Pow!

"Rocky"

Breast cancer sisters 
Terlisa Sheppard and Melissa

#KissThis4MBC

Melissa and Josh Levin of
 lymphedivas.com

TNBC sister, Sara K. showing off
her new sleeve just purchased from
a vendor, 
lymphedivas.com


Cheers! 
Party-crasher of a cancer fundraiser!

Triple Negative Breast Cancer sisters
Addys S. and Melissa

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