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"I promise, Suzy... Even if it takes the rest of my life." - Nancy G. Brinker, founder of Susan G. Komen for the Cure

What is Triple Negative Breast Cancer?


Just in recent years, Triple Negative Breast Cancer has sparked interest in the news where instead of calling the tumor as ER-negative, PR-negative, and HER2-negative; researchers began using the shorthand term, "Triple Negative," dubbed the "new type" type of cancer. Being Triple Negative, you don't have a targeted therapy and that your only treatment option is chemotherapy.

Triple Negative is seen in about 15% of all breast cancers. Triple Negative is a very aggressive cancer that tends to strike younger women, pre-menopause, especially among African-American women and women who have BRCA1 mutations. The tumor tends to be fast growing and is less likely to show up on an annual mammogram. TN is more likely to metastasis early on; has a high rate of recurrence in the first 2-3 years from diagnosis and has a poorer prognosis than other types of breast cancer due to lack of specific, targeted treatment for TNBC.

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Saturday, August 25, 2012

FDA Seeks To Speed Drug Development For Early-Stage, Triple-Negative Breast Cancer

"Here’s how it would work: a drug would be tested in the neoadjuvant (before-surgery) setting among patients with early-stage cancer. Study participants would receive standard chemotherapy alone or in combination with the investigational drug. The response to these treatments would be assessed at the time of breast cancer surgery. If the addition of the investigational drug produces higher pCR rates than chemotherapy alone, the drug may be considered for accelerated approval."

FDA Seeks to Speed Drug Development for Early-Stage, Triple-Negative Breast Cancer (Click to read full story)

1 comment:

  1. Thanks for sharing. We need all we can get to move faster to answers. And I hope we get better at determining which of these treatments is best for which TN.

    As far as testing drug BEFORE surgery, I was in a clinical trial and it was found that the new drug actually wiped out large tumors if given before surgery which sounds very cool. Don't know what they are finding as far as long-term outcomes with this drug, which is called Ixibipilone. Melissa, keep up the good work keeping us all informed of the latest with TN.


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