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"I promise, Suzy... Even if it takes the rest of my life." - Nancy G. Brinker, founder of Susan G. Komen for the Cure

What is Triple Negative Breast Cancer?

WHAT IS TRIPLE NEGATIVE BREAST CANCER?

Just in recent years, Triple Negative Breast Cancer has sparked interest in the news where instead of calling the tumor as ER-negative, PR-negative, and HER2-negative; researchers began using the shorthand term, "Triple Negative," dubbed the "new type" type of cancer. Being Triple Negative, you don't have a targeted therapy and that your only treatment option is chemotherapy.

Triple Negative is seen in about 15% of all breast cancers. Triple Negative is a very aggressive cancer that tends to strike younger women, pre-menopause, especially among African-American women and women who have BRCA1 mutations. The tumor tends to be fast growing and is less likely to show up on an annual mammogram. TN is more likely to metastasis early on; has a high rate of recurrence in the first 2-3 years from diagnosis and has a poorer prognosis than other types of breast cancer due to lack of specific, targeted treatment for TNBC.

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Friday, January 24, 2014

Researchers Link Protein With Breast Cancer's Spread to the Brain

"Furthermore, the team found breast tumors that expressed alphaB-crystallin were more likely to be triple-negative breast cancers - an aggressive type of cancer, which lacks three receptors (estrogen receptor, progesterone receptor and HER-2) expressed in other types of breast cancer. Triple-negative breast cancers are known to have a high incidence of brain metastasis."

“Our findings suggest that alphaB-crystallin may contribute to the tendency of triple-negative breast cancers to metastasize to the brain and to their poor prognosis,” said Cryns. Yet, he cautioned these findings need to be validated in additional studies."

http://www.med.wisc.edu/news-events/uw-madison-researchers-link-protein-with-breast-cancers-spread-to-the-brain/42519  (Click link to complete story)

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