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"I promise, Suzy... Even if it takes the rest of my life." - Nancy G. Brinker, founder of Susan G. Komen for the Cure

What is Triple Negative Breast Cancer?


Just in recent years, Triple Negative Breast Cancer has sparked interest in the news where instead of calling the tumor as ER-negative, PR-negative, and HER2-negative; researchers began using the shorthand term, "Triple Negative," dubbed the "new type" type of cancer. Being Triple Negative, you don't have a targeted therapy and that your only treatment option is chemotherapy.

Triple Negative is seen in about 15% of all breast cancers. Triple Negative is a very aggressive cancer that tends to strike younger women, pre-menopause, especially among African-American women and women who have BRCA1 mutations. The tumor tends to be fast growing and is less likely to show up on an annual mammogram. TN is more likely to metastasis early on; has a high rate of recurrence in the first 2-3 years from diagnosis and has a poorer prognosis than other types of breast cancer due to lack of specific, targeted treatment for TNBC.

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Monday, May 5, 2014

Tumour Cell Genome Studies Give Rise to Individualized Therapy

" ...have documented 80 different types of an aggressive form of breast
cancer, called triple negative, defined by the absence of three hormone
receptors. Triple negative breast cancers represent about 16 per cent of breast cancers and, until the BC Cancer Agency’s work, had been treated as a single disease, often with little success. “The great advance of genomics is that we can now see how different they all are,” said Marra. Marra and Aparicio also found that cells within a single breast cancer tumour may contain different mutations, thus creating a mosaic of cells all evolving independently that each respond to treatment differently. That means drugs that kill cells with a specific mutation could easily leave other cancer cells unscathed to start new tumours. Cancer treatments would have to be targeted to the genome of all the cancer cells in a tumour to be effective, he said."

Click link to read full story:
Tumour cell genome studies give rise to individualized therapy

1 comment:

  1. My oncologist explained to me that while TNs have a short term bleaker outlook, long term, if we get past the 5 to 6 year mark, we have a better chance of remission/survival. I very clearly remember him telling me this at Roswell Park in Buffalo,


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