I promise

"I promise, Suzy... Even if it takes the rest of my life." -Nancy G. Brinker, Founder of Susan G. Komen for the Cure

What is TNBC

WHAT IS TRIPLE NEGATIVE BREAST CANCER?

Just in recent years, Triple Negative Breast Cancer (TNBC) has sparked interest in the news where instead of calling the tumor as ER-negative, PR-negative, and HER2-negative; researchers began using the shorthand term, "Triple Negative," dubbed the "new type" of breast cancer. Being Triple Negative, you don't have a targeted therapy and your only treatment option is chemotherapy.

Triple Negative Breast Cancer is seen in about 15% of all breast cancers. TNBC is a very aggressive cancer that tends to strike younger women, pre-menopause, especially among African-American women and women who have BRCA1 mutations. The tumor tends to be fast growing and is less likely to show up on an annual mammogram. TNBC is more likely to metastasis early on; has a high rate of recurrence in the first 2-3 years from diagnosis and has a poorer prognosis than other types of breast cancer due to lack of specific, targeted treatment for TNBC.

Sunday, November 16, 2014

CDX-011 Study Gives Triple Negative Breast Cancer Patients New Hope

“This is the most promising phase 3 trial in triple negative breast cancer in the last five years, since the phase 3 trial with the PARP inhibitor iniparib,” says Cleveland Clinic oncologist and principal investigator Alberto Montero, MD. “CDX-011 is a novel targeted drug for a disease that is defined clinically by the absence of any targets. A potent chemotherapy is delivered in a targeted fashion by being attached to an antibody that recognizes GPNMB, which is overexpressed in about 25 to 30 percent of all triple negative breast cancers.”
Click link to read full article:
http://consultqd.clevelandclinic.org/2014/11/clinical-trial-tests-targeted-breast-cancer-therapy 

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