I promise

"I promise, Suzy... Even if it takes the rest of my life." -Nancy G. Brinker, Founder of Susan G. Komen for the Cure

What is TNBC

WHAT IS TRIPLE NEGATIVE BREAST CANCER?

Just in recent years, Triple Negative Breast Cancer (TNBC) has sparked interest in the news where instead of calling the tumor as ER-negative, PR-negative, and HER2-negative; researchers began using the shorthand term, "Triple Negative," dubbed the "new type" of breast cancer. Being Triple Negative, you don't have a targeted therapy and your only treatment option is chemotherapy.

Triple Negative Breast Cancer is seen in about 15% of all breast cancers. TNBC is a very aggressive cancer that tends to strike younger women, pre-menopause, especially among African-American women and women who have BRCA1 mutations. The tumor tends to be fast growing and is less likely to show up on an annual mammogram. TNBC is more likely to metastasis early on; has a high rate of recurrence in the first 2-3 years from diagnosis and has a poorer prognosis than other types of breast cancer due to lack of specific, targeted treatment for TNBC.

Monday, April 1, 2013

TGF-b Inhibitors Needed to Target Stem-Like Cancer Cells In Triple Negative Breast Cancer

"A new study by Vanderbilt-Ingram Cancer Center investigators suggests drugs that block or inhibit the TGF-b signaling pathway in cancer cells enhance the effect of chemotherapy and may prevent recurrences of treatment-resistant TNBC..."
...Chemotherapy drugs are designed to attack fast-dividing cancer cells. Recent research suggests that after an initial response to chemotherapy a small population of slower growing cells known as cancer stem-like cells (CSCs) survives and regenerates, causing metastatic tumor recurrences...
http://news.vanderbilt.edu/2013/03/breast-cancer-study-explores-therapy-to-slow-recurrence/
(Click link to story)

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